The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines
The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines
Blog Article
IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic, vitamin D has been established as an immune-modulator that reduces pro-inflammatory damage which effectively opheliasmuse.com diminish the severity of COVID-19.Vitamin D also has a significant effect against influenza and dengue and increase the seroconversion following influenza vaccination.To date, the role of vitamin D in optimizing the efficacy of COVID-19 vaccines remains unclear.
This study aimed to analyze the correlation between serum 25-hydroxy-cholecalciferol or 25(OH)D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients.MethodologyA multicenter cross-sectional study was conducted among solid and hematologic cancer patients who were vaccinated with two doses of the same types of COVID-19 vaccines (either mRNA, non-replicating viral vector, or inactivated) within 6 months.ResultThe median serum 25(OH)D level in 119 cancer patients was 36.
36 [IQR = 30.30] ng/mL.The seropositivity of S-RBD IgG and NAb reached 93.
3 and 94.1%, respectively.The S-RBD IgG level was significantly higher in the sufficient group (median = 414.
07 [1,441.83] AU/mL) than in the deficient group (median = 91.56 [652.
00] AU/mL) (p-value = 0.049).Among non-chemotherapy subjects, the anti-SARS-CoV-2 S-RBD IgG levels had a significant positive correlation with 25(OH)D levels (p-value = 0.
03; R = 0.588).The NAb levels also showed significantly positive correlation with 25(OH)D level (p-value = 0.
005; R = 0.561).The 25(OH)D levels were positively correlated with S-RBD IgG levels among subjects younger than 60 years old (p-value = 0.
047; R = 0.136).However, serum 25 (OH)D levels showed no such correlation with S-RBD IgG levels among subjects older than 60 years old (p-value = 0.
933; R = 0.136).ConclusionBoth anti-SARS-CoV-2 S-RBD IgG and NAb levels developed moderate correlation with 25(OH)D levels among subjects treated without chemotherapy.
The S-RBD IgG levels also had positive correlation with 25(OH)D levels among subjects chainsaw file younger than 60 years old.Thus, we recommended cancer patients to maintain serum 25(OH)D levels above 30 ng/mL (75 nmol/L) to enhance the efficacy of COVID-19 vaccines.